The Company


Advanced BioMatrix is a leader in the life science of three dimensional (3D) applications for tissue culture, cell assay, bioprinting and cell proliferation. Our products are recognized as the standard for purity, functionality and consistency.

We have extensive expertise in production, isolation, purification, lyophilization, cell culture and testing of proteins, adhesion peptides, attachment factors, bioinks, substrate rigidity, and other 3D matrix products. Our expertise and knowledge are being employed to assure that our products are of the highest quality, consistent from lot-to-lot and easy-to-use for our research customers. See our expertise.  

The company is located in the San Diego region – one of the world’s largest life science and biotechnology clusters.   Advanced BioMatrix has been manufacturing and delivering high quality products for research uses and applications for over 10 years.  We continue to add several innovative new products each year that provide research tools for our customers worldwide.  We develop new products and technologies within our company and also collaborate with many research institutes, universities and life science companies.

We are committed to our company vision of "Transforming science to a new level of discovery by providing advanced technologies through innovative 3D matrix products."

 

Facilities


Advanced BioMatrix’s facilities are located in the San Diego region in Carlsbad, California, USA.  Our state-of-the-art 7,300 sq. ft facility is designed for operational efficiency of materials, personnel and activities.  Controls have been instituted to segregate operations where necessary to avoid mix-ups and possible contamination.  Facility suites have been built for raw material preparation, clean room manufacturing, quality control, cell culture, bioprinting, R&D labs, fabrication of rigidity cultureware and cold chain distribution.  Our order fulfillment, technical and customer service functions are closely housed to provide optimal service to our customers.

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Lyophilizers
Bioprinting
Manufacturing Expertise

Our broad production technology and expertise is based on years of manufacturing experience that provides a platform for the manufacturing of products that meet the highest standards. These capabilities include:

  • Sterile Filtration
  • Aseptic Processing and Filling
  • Ultrafiltration and Diafiltration
  • Autoclaving, Irradiation and Ozone
  • Blending and Homogenization
  • Particle Size Reduction and Grinding
  • Protein Isolation and Purification
  • Clarification and Ion Exchange 
  • Lyophilization
  • 3D Bioprinting
  • Sonication
  • Silicone Dispensing
  • Centrifugation
  • Crosslinking (Photo, Chemical, Thermal)

Quality Control


Our quality control program and testing  provide a platform for ensuring that our products meet the highest quality standards and specifications. Our stringent quality control requirements help ensure lot-to-lot consistency, giving you confidence in your research. Our core testing and analytical capabilities include:

 

  • Protein Analysis (Biuret and BCA)
  • Cell Culture, Attachment and Live/Dead Assays
  • Kinetic Gel Tests
  • pH
  • Osmolality
  • Fibrillogenesis
  • Viscosity
  • Differential Scanning Calorimetry
  • Rheometry
  • SDS Page Electrophoresis Coomassie Staining
  • SDS Page Electrophoresis Silver Staining
  • Sterility
  • Endotoxin
  • Collagen Solubility and Denaturation Assay
  • Amino Acid Analysis
  • Microscopy Size Measurements

Quality System


Our quality system is carried out to meet the aims of our Quality System Policy which is “at all times, it is our responsibility as employees to develop, manufacture and distribute products that meet our quality standards and customer’s needs”.  See quality system elements described below:

  • Material Traceability
  • Documentation - Sepcifications, SOP's, Batch Records, Release Criteria
  • Equipment Calibration, Certification and Testing
  • Personnel Training
  • Supplier and Service Provider Controls
  • Maintenance and Facility Controls
  • Import and Export Procedures
  • Cold Chain and Shipping
  • Clean Room and Particle Counter
  • Water Purification Expertise

Why 3D Matters


The behavior of 3D-cultured cells is more reflective of in vivo cellular responses. 3D cell culture systems represent more accurately the actual microenvironment found in tissues in the body. Research has shown that cells in a 3D culture environment differ morphologically and physiologically from cells in a 2D culture environment. 

The additional dimensionality of 3D culture is the crucial feature leading to the difference in cellular responses because not only does it influence the spatial organization of the cell surface receptors engaged in interactions with surrounding cells, but it also induces physical constraints to cells. These spatial and physical aspects in 3D cultures affect the signal transduction from the outside to the inside of the cells, and ultimately influence gene expression and cellular behavior.   The adjacent diagram provides a depiction of the effects of 3D verse 2D of cell culture systems.

3D Cell Culture (versus 2D)


Differentiation - Increases the differentiation activity of certain stem cells and increases the duration of undifferentiated state of other stem cells

Drug Metabolism - Decreases the anti-proliferative effect of some anticancer drugs and increases albumin and urea production

Gene Expression - Causes different levels of gene expression and enables expression of some genes that do not express in 2D

General Cell Function - Enhances performance and functional activity of human liver cells and induces well developed cell-cell contact

Morphology - Induces clear differences in morphology, arrangement and polarization and increases the neurite extension length

Proliferation - Increases growth rate and attachment of mesenchymal stem cells and decreases proliferation of breast cancer cells

Response to Stimuli - Decreases responsiveness to intracellular Ca2+ and decreases response to K+

Viability - Increases long term cell growth and supports cell survival under conditions of calcium and nutrient deprivation 

 

 

Source: http://3dcellculture.com/just_the_facts_3D_vs_2d_cell_culture

Collaborations


Advanced BioMatrix has a flexible and versatile mindset looking for opportunities to collaborate with many entities to bring new technologies and products to its customers. 

We have worked closely with companies of all sizes, universities, research institutes, suppliers, customers and individuals to translate technology into products and tools that help researchers solve problems and make scientific break-throughs.