Collagen Hybridizing Peptides
The CHP probe may be well suited for visualization of ECM remodeling events in 3D collagen gels cause by cancer cell migration, vascular sprouting, skin inflammation, and macrophage polarization, as well as on modern tissue culture platforms, including organoids and organ-on-a-chip.
The degraded collagen fibrils in the 3D collagen hydrogel (right) are directly labeled with CHP through triple helical hybridization, whose signals are readily detected by a standard fluorescence confocal microscope.
Akura Spheroid and Organoid Plates
The ultimate spheroid screening plate unifies robust liquid and spheroid handling with automated high-throughput screening applications. The flat bottom and black walls of the InSphero 384 well plate facilitate confocal imaging, while the special well design allows medium exchange, dosing, and endpoint determination in the same plate saving time and resources.
The 3-in-1 plate allows for researchers to culture spheroids or organoids (mono/co-cultured), embed them in an extracellular matrix, test drugs & perform downstream analysis - All without ever having to remove them from the platform.
Explore the plate here.