3D Lung Epithelial Tissue Model
09/21/20
Publication Title:
Mannose Receptor-Derived Peptides Neutralize Pore-Forming Toxins and Reduce Inflammation and Development of Pneumococcal Disease
Advanced BioMatrix Products Used:
How the products were used:
Our type I collagen was used to set up a 3D lung epithelial tissue model to study novel therapeutics for treating bacterial infections.
Abstract:
Co-administration of peptide-loaded CaP NPs during infection improved survival and bacterial clearance in both zebrafish and mice models of pneumococcal infection. We suggest that MRC-1 peptides can be employed as adjunctive therapeutics with antibiotics to treat bacterial infections by countering the action of CDCs.
