Biomaterial for Islet Transplantation

Biomaterial for Islet Transplantation

07/14/20

Publication Title:

A Scalable Device-less Biomaterial Approach for Subcutaneous Islet Transplantation

 

Advanced BioMatrix Products Used: 

PureCol® Type I Collagen

Type I Collagen eBrochure

 

How the products were used:

Pancreatic Islets were mixed with neutralized PureCol Type I Collagen prior to transplantation.

 

Article Abstract:

In this study methacrylic acid copolymer coated tubes generated a robust vascular response in the subcutaneous space, which was critical to support islet transplantation in a streptozotocin-induced diabetic mouse model. More importantly, the subcutaneous pre vascularization approach using this copolymer coating was scalable into a larger allogeneic rat model and returned animals to normoglycemia for up to 70 days. This platform highlights the potential of a scalable biomaterial approach for pre-vascularization of the subcutaneous space in larger animal models.

 

 Link to the publication: 

https://www.biorxiv.org/content/10.1101/2020.06.26.172148v1.full


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