Comparison of Alzheimer's Variants
09/21/20
Publication Title:
Multi-omic Comparison of Alzheimer's Variants in Human ESC-Derived Microglia Reveals Convergence at APOE
Advanced BioMatrix Products Used:
VitroCol® Human Type I Collagen
How the products were used:
ECM Select was used to determine the optimal ECM substrate for microglia cells. Tropoelastin and Type I collagen were then used for culturing hMGL cells in this study.
Abstract:
Variations in many genes linked to sporadic Alzheimer’s disease (AD) show abundant expression in microglia, but relationships among these genes remain largely elusive. Using this modeling and analysis platform for human microglia, we provide new insight into epistatic interactions in AD genes and demonstrate convergence of microglial AD genes at the APOE locus.
