Evaluation of ACKR3 for Postnatal Lymphangiogenesis
04/27/21
Publication Title:
Lymphatic Endothelial-Cell Expressed ACKR3 is Dispensable for Postnatal Lymphangiogenesis and Lymphatic Drainage Function in Mice
Advanced BioMatrix Products Used:
PureCol® Type I Collagen, Atelocollagen, 3 mg/ml
How the products were used:
PureCol® type I collagen used for seeding digested tissue fragements and subsequently isolating dermal stromal cells.
Article Conclusion:
"We show that ACKR3 is widely expressed in mature lymphatics and that it exerts chemokine-scavenging activity in cultured murine skin-derived LECs. To investigate the role of LEC-expressed ACKR3 in postnatal lymphangiogenesis and function during adulthood, we generated and validated a lymphatic-specific, inducible ACKR3 knockout mouse. Surprisingly, in contrast to the reported involvement of ACKR3 in lymphatic development, our analyses revealed no contribution of LEC-expressed ACKR3 to postnatal lymphangiogenesis, lymphatic morphology and drainage function."
Link to the publication:
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0249068
