Macrophage Response to Injectable Hydrogels
06/03/20
Publication Title:
Host macrophage response to injectable hydrogels derived from ECM and α-helical peptides.
Advanced BioMatrix Products Used:
Type I Collagen Hydrogels eBrochure
How the products were used:
FibriCol® 10 mg/ml type I collagen was used as an injectable hydrogel to study host macrophage response in tissue healing.
Article Abstract:
Over 28 days in rat abdominal wall we observe an increase in mononuclear cell infiltration at the hydrogel-tissue interface with no foreign body reaction, no evidence of hydrogel encapsulation and no multinucleate giant cells.
Our data indicate pro-remodelling and the
promotion of an anti-inflammatory environment for all injected hydrogels with evidence of full integration with healthy tissue after 28 days. These unique materials offer great potential for future applications in regenerative medicine and towards designing materials for unmet clinical
needs.
Link to the publication:
https://www.sciencedirect.com/science/article/abs/pii/S1742706120302920
