Replicating the Human Body
01/17/23
Importance of Replicating the Human Body in Research
Growing cells on standard plastic cultureware eliminates all in vivo benefits of the extracellular matrix. At Advanced BioMatrix, we provide highly purified extracellular matrix proteins to help create a natural environment for cells. Surrounding cells with the correct environmental cues leads to more physiologically relevant research and discoveries.
The extracellular matrix (ECM) is a three-dimensional network of proteins, enzymes, glycosaminoglycans and other macromolecules that provide structural and biochemical support of surrounding cells. The ECM is critical for cellular adhesion, communication, growth, migration, differentiation, and countless other functions.
These extracellular matrices include prominent proteins such as:
Collagen I, Collagen II, Collagen III, Collagen IV, Tropoelastin, Vitronectin, Fibronectin, Laminin
Composition of the Human Body ECM
The table to the right provides a list of components identified in human fibroblast-produced ECM. Assays for other ECM component were either not available or feasible at the time this experimental work was done. The results do provide, in general, important information regarding the composition and relative quantities of ECM components tested.
As a result,collagen I protein is found to be the most abundant ECM protein in the human body, followed by Glucosaminoglycans such as Hyaluronic Acid.
