SpongeCol Based Stromal Reticula
07/14/20
Publication Title:
Tissue-Engineered Stromal Reticula to Study Lymph Node Fibroblastic Reticular Cells in Type I Diabetes
Advanced BioMatrix Products Used:
SpongeCol® Type I Collagen Sponge
How the products were used:
SpongeCol collagen sponges were used as the core scaffold for creating tissue-engineered stromal reticula.
Article Abstract:
In Type 1 diabetes (T1D), decrease in FRC frequency and in their expression of T1D-related self-antigens may hinder tolerogenic engagement of autoreactive T cells. FRC reticular organization in LNs is critical for adaptive immunity. Thus, we engineered LN-like FRC reticula to determine if FRC reticular properties were altered in T1D and to study engagement of autoreactive T cells in vitro.
Link to the publication:
https://link.springer.com/article/10.1007/s12195-020-00627-y
