SpongeCol Based Stromal Reticula

SpongeCol Based Stromal Reticula

07/14/20

Publication Title:

Tissue-Engineered Stromal Reticula to Study Lymph Node Fibroblastic Reticular Cells in Type I Diabetes

Advanced BioMatrix Products Used: 

SpongeCol® Type I Collagen Sponge

Type I Collagen eBrochure

 

How the products were used:

SpongeCol collagen sponges were used as the core scaffold for creating tissue-engineered stromal reticula.

 

Article Abstract:

In Type 1 diabetes (T1D), decrease in FRC frequency and in their expression of T1D-related self-antigens may hinder tolerogenic engagement of autoreactive T cells. FRC reticular organization in LNs is critical for adaptive immunity. Thus, we engineered LN-like FRC reticula to determine if FRC reticular properties were altered in T1D and to study engagement of autoreactive T cells in vitro.

 

 Link to the publication: 

https://link.springer.com/article/10.1007/s12195-020-00627-y


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