VitroCol for Tumor Spheroids
01/23/24
Publication Title:
Automated Analysis of Extracellular Matrix Invasion of Cancer Cells from Tumor Spheroids
Advanced BioMatrix Products Used:
Type I Collagen Hydrogels eBrochure
How the products were used:
VitroCol Type I Human Collagen was used to culture spheroid cancer cells in order to study the extracellular matrix invasion of cancer cells.
Conclusion:
We demonstrated that this method resolves cell invasion from spheroids of different shapes and sizes and from cells that invade as a cluster or individually. We also showed that this approach can help quantify the dose-dependent anti-invasive effects of a commonly used chemotherapy drug. Our automated method significantly reduces the time and increases the consistency and accuracy of cancer cell invasion analysis in three-dimensional cultures.
Link to the publication:
https://pubs.acs.org/doi/full/10.1021/acsmeasuresciau.3c00064
