3D Bioprinting PureCol EZ Gel
03/07/24
Publication Title:
Spatial Engineering of Mammary Epithelial Cell Cultures with 3D Bioprinting Reveals Growth Control by Branch Point Proximity
Advanced BioMatrix Products Used:
PureCol® EZ Gel Type I Collagen, Atelocollagen, 3 mg/ml
How the products were used:
PureCol EZ Gel was mixed with Matrigel and 3D bioprinted. The researchers 3D bioprinted normal and cancerous mammary epithelial cells into branched y-shape to study the role of cell positioning in the regulation of cell proliferation and invasion.
Article Conclusion:
"Our data demonstrate that the 3D-bioprinted cells can sense their position in the branched network of cells and proliferate at the tips, thus recapitulating this feature of mammary epithelial branching morphogenesis. In all, our results demonstrate the capacity of the developed 3D bioprinting method for quantitative analysis of the relationships between tissue structure and cell behavior in breast morphogenesis and cancer."
Link to the publication:
https://link.springer.com/article/10.1007/s10911-024-09557-1
