Breast Cancer Tissue Model with Glycosil
04/07/21
Publication Title:
Bioprinting and Differentiation of Adipose-Derived Stromal Cell Spheroids for a 3D Breast Cancer-Adipose Tissue Model
Advanced BioMatrix Products Used:
Glycosil® Thiolated Hyaluronic Acid
How the products were used:
Glycosil® thiolated hyaluronic acid was used to create a novel bioink for printing adipose derived stromal cell spheroids, helping to create novel breast cancer tissue models.
Article Conclusion:
After nine days of co-culture, we observed a cancer cell-induced reduction of the lipid content and a remodeling of the ECM within the adipose tissues, with increased fibronectin, collagen I and collagen VI
expression.Together, our data demonstrate that 3D-printed breast cancer-adipose tissue models can recapitulate important aspects of the complex cell–cell and cell–matrix interplay within the tumor-stroma microenvironment.
Link to the publication:
https://www.mdpi.com/2073-4409/10/4/803
