3D Proliferation Assay with PureCol
02/20/20
Publication Title:
FGF13 Promotes Metastasis of Triple-Negative Breast Cancer
Advanced BioMatrix Products Used:
PureCol® Type I Collagen Solution, 3 mg/ml
How the products were used:
PureCol® type I collagen was used to form 3D hydrogels for an "In Vitro Proliferation Assay" in assessing new molecular targets for therapeutic intervention of breast cancer.
Article Abstract:
We conducted RNA expression analysis on four isogenic MDA-MB-231 TNBC tumour models that differed in metastatic capacity. Here we identify FGF13 upregulation in metastatic MDA-MB-231 variants. Higher FGF13 expression was associated with worse survival in patients with basal-like breast cancer and knockdown of FGF13 in MDA-MB-231_HM cells markedly reduced spontaneous metastasis to liver and lung in mice without affecting primary xenograft growth. Our results indicate that FGF13 could be a novel target for anti-metastasis therapy.
Link to the publication:
