Activation of Fibroblast Modulated by Stiffness
11/24/20
Publication Title:
TGF-Beta-Induced Activation of Conjunctival Fibroblasts is Modulated by FGF-2 and Substratum Stiffness
Advanced BioMatrix Products Used:
CytoSoft® PDMS Soft Substrate Plates
How the products were used:
CytoSoft® Plates (6-well plates with a thin layer of PDMS of a specific stiffness, including 0.2, 0.5, 2, 8, 16, 32 and 64 kPa) were used to evaluate the induction of alpha-SMA by TGF-Beta2 on softer versus harder substrates.
Article Conclusion:
FGF-2 treatment and a soft substratum suppressed TGF-Beta-Induced transdifferentiation of conjunctival fibroblasts into myofibroblasts.
Link to the publication:
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0242626
