Beating Cardiac Tissue

Publication Title:

Electroconductive Biohybrid Hydrogel for Enhanced Maturation and Beating Properties of Engineered Cardiac Tissues

Advanced BioMatrix Products Used: 

RatCol^® 4 mg/ml type I telocollagen

How the products were used:

Our rat tail type I collagen (4 mg/ml) was used to form a 3D hydrogel encapsulating neonatal rat cardiomyocytes. The cells exhibited ehanced beating frequency, speed of contraction, and larger contraction amplitude. 

Abstract:

Here, a biohybrid hydrogel composed of collagen, alginate, and electroconductive poly(3,4‐ethylenedioxythiophene) :polystyrene sulfonate (PEDOT:PSS) is developed that exhibits extracellular matrix mimetic fibrous structures and enhanced electrical coupling as well and cardiomyocyte maturation.