Collagen Stiffness Affects Spheroid Migration
08/02/23
Publication Title:
Matrix Stiffness Modulates 3D Spheroid Sorting and Burst-like Collective Migration
Advanced BioMatrix Products Used:
RatCol® - Rat Tail Type I Collagen, 4 mg/ml
How the products were used:
Researchers created a collagen/alginate hydrogel for embedding spheroids. The stiffness of the hydrogel was able to be mechanically tuned via chemical crosslinking.
Reducing the substrate stiffness triggers a collective fluidization of cell motion.
Article Conclusion:
The findings support a model where matrix stiffness modulates 3D spheroid sorting and unjamming in an adhesion-dependent manner, providing insights into the mechanisms of cell sorting and migration in the primary tumor and toward distant metastatic sites.
Link to the publication:
https://www.biorxiv.org/content/10.1101/2023.07.23.549940v1.full
