CytoSoft and hPSCS
03/07/24
Publication Title:
Assessment of Human Embryonic Stem Cells Differentiation into Definitive Endoderm Lineage on the Soft Substrates
Advanced BioMatrix Products Used:
CytoSoft® PDMS Soft Substrate Plates
How the products were used:
CytoSoft® Plates (soft substrate 6-well plates with a thin layer of PDMS of a specific stiffness, including 0.2, 0.5, 2, 8, 16, 32 and 64 kPa) were used to evaluate the affect of matrix stiffness on iPSC differentiation towards endoderm and then into functional pancreatic progenitor cells.
Article Conclusions:
The results suggest that human embryonic stem cells may not differentiate in response to changes in stiffness, and that such cues may not have a significant impact on the level of YAP, though more research is needed.
Link to the publication:
https://onlinelibrary.wiley.com/doi/full/10.1002/cbin.12151
