FibriCol Tumor on a Chip Model
09/20/23
Publication Title:
3D-Printed Tumor-on-a-Chip Model for Investigating the Effect of Matrix Stiffness on Glioblastoma Tumor Invasion
Advanced BioMatrix Products Used:
How the products were used:
FibriCol was used to culture U251 Tumoroids within a 3D printed microfluidic device.
Article Conclusion:
Results revealed that tumoroids exhibit two distinct patterns of invasion in response to the concentration of collagenase, namely ring-type and finger-type patterns. Moreover, higher concentrations of collagenase resulted in greater invasion lengths, confirming the strong dependency of tumor behavior on the stiffness of the surrounding matrix. The agreement between the experimental results and the model’s predictions demonstrates the advantages of this approach in investigating the impact of various extracellular matrix characteristics on tumor growth and invasion.
Link to the publication:
https://www.mdpi.com/2313-7673/8/5/421
