Fibrotic Microtissue Model
08/02/23
Publication Title:
Modeling Mechanical Activation of Macrophages During Pulmonary Fibrogenesis for Targeted Anti-Fibrosis Therapy
Advanced BioMatrix Products Used:
RatCol® - Rat Tail Type I Collagen, 4 mg/ml
How the products were used:
Researchers used rat tail collagen to help create fibrotic microtissue models, cocultured with human macrophages and fibroblasts.
Anti-fibrosis treatments were used on the microtissue models, helping understand the pulmonary fibrogenesis mechanism at the tissue level contributed by mechanically activated macrophages.
Article Conclusion:
The researchers proposed the use of their "coculture, force-sensing microtissue model as a powerful tool to study the complex immune-stromal cell interactions and the mechanism of action of anti-fibrosis drugs."
Link to the publication:
https://www.biorxiv.org/content/10.1101/2023.07.19.549794v1.full
