Heprasil for 3D Printed Microvessels
07/19/23
Publication Title:
A Next-Generation 3D Tissue-Engineered Model of the Human Brain Microvasculature to Study the Blood-Brain Barrier
Advanced BioMatrix Products Used:
Heprasil® Thiolated Hyaluronic Acid + Thiolated Heparin
How the products were used:
Heprasil® was used to help with the endotheliazation of 3D-Printed microvessels.
PEGDA/GelMA mixture bioinks were printed on the Cellink Lumen X printer. Constructs were coated with Heprasil®, a thiolated hyaluronic acid/thiolated heparin mixture.
The construct was then cellularized with primary human brain microvascular endothelial cells and pericytes.
Article Conclusion:
The group has concluded that "constructs are validated for complete endothelialization with viability dyes prior to functional assessments that include barrier integrity (permeability) and immune-endothelial interactions. This MPS has applications for the study of novel therapeutics, toxins, and elucidating mechanisms of pathophysiology."
Link to the publication:
https://www.mdpi.com/2306-5354/10/7/817
