HyStem-HP Injection for Neural Repair

HyStem-HP Injection for Neural Repair

09/14/20

Publication Title:

Epicortical Brevetoxin Treatment Promotes Neural Repair and Functional Recovery after Ischemic Stroke

 

Advanced BioMatrix Products Used: 

HyStem®-HP Thiolated Hyaluronic Acid Kit

 

How the products were used:

HyStem®-HP was used as the injectate/carrier for delivering Brevetoxin-2 (PbTx-2) into the epicortical region of the brain for improving post-stroke recovery. 

Abstract:

We show that PbTx-2 enhanced the dendritic arborization and synapse density of cortical layer V pyramidal neurons in the peri-infarct cortex. PbTx-2 also produced a robust improvement of motor recovery. These results suggest a novel pharmacologic approach to mimic activity-dependent recovery from stroke.

Link to the publication:

https://www.mdpi.com/1660-3397/18/7/374/htm 


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