Immunofluorescence Staining of Collagen
04/22/24
Publication Title:
A Phenotypic Screening Approach to Target p60AmotL2-expressing Invasive Cancer Cells
Advanced BioMatrix Products Used:
PureCol® Type I Collagen, Atelocollagen, 3 mg/ml
How the products were used:
PureCol Collagen was used for culturing cells in 3D, prior to fixing and immunofluorescence staining. This was part of a study analyzing migration and invasion of tumor cells into adjacent tissues.
Article Conclusion:
BET inhibitors specifically target p60AmotL2-expressing invasive cancer cells, likely by exploiting differences in chromatin accessibility, leading to cell death. Additionally, our findings support the use of this phenotypic strategy to discover novel compounds that can exploit vulnerabilities and specifically target invasive cancer cells.
Link to the publication:
https://link.springer.com/article/10.1186/s13046-024-03031-w
