Mechanotransduction and Breast Cancer
03/15/24
Publication Title:
Deciphering the Mechanotransduction Symphony: Stiffness-Dependent Interplay of YAP and B-Catenin in Breast Cancer Metastasis
Advanced BioMatrix Products Used:
CytoSoft® PDMS Soft Substrate Plates
How the products were used:
CytoSoft® Plates (soft substrate 6-well plates with a thin layer of PDMS of a specific stiffness, including 0.2, 0.5, 2, 8, 16, 32 and 64 kPa) were used to evaluate the affect of matrix stiffness on the nuclear translocation of YAP and B-Catenin in MDA-MB-231 cells exposed to stiff and soft substrates.
Article Conclusions:
"Our investigation revealed the significant impact of myosin-II and cell confluency on the interplay between YAP and β-catenin. Thus, we elucidated a paradigm in which β-catenin assumes a compensatory role in response to YAP knockdown, particularly under distinct mechanical conditions. The interplay is finely tuned to the mechanical microenvironment, highlighting the mechanosensitivity of this compensatory mechanism."
Link to the publication:
https://www.authorea.com/doi/full/10.22541/au.171008008.88635673
