MSCs in Rat Tail Collagen
04/07/21
Publication Title:
Continuous Low-Intensity Ultrasound Preserves Mitochondrial Potential, Inhibits NFkB Activation and Rescues Chondrogenesis of Mesenchymal Stromal Cells
Advanced BioMatrix Products Used:
RatCol® Rat Tail Collagen, 4 mg/ml, #5153-1KIT
How the products were used:
MSCs were embedded in a rat tail collagen hydrogel in a unique study designed to improve cartilage repair. This group discovered novel strategies that minimized the deleterious effects of activated NFkB, while promoting MSC Chondrogenesis.
Article Conclusion:
Chondroinductive potential of cLIUS was preserved as noted by the increased expression of SOX9 and deposition of collagen II. cLIUS extended its chondroprotective effects by stabilizing the NFκB complex in the cytoplasm via engaging the IκBα feedback mechanism, thus preventing its nuclear translocation. cLIUS acted as a mitochondrial protective agent by restoring the mitochondrial potential and the mitochondrial mRNA expression in a proinflammatory environment.
Link to the publication:
https://www.researchsquare.com/article/rs-342462/v1
