PhotoGel and PhotoHA Hydrogel Stiffness
09/15/21
This study was performed as a joint collaboration between Rheolution (QC, Canada) and Advanced BioMatrix (CA, USA).
SUMMARY
- Gelatin and hyaluronic acid are abundant components extracted from human tissues and therefore, they have an inherent biocompatibility.
- Photocrosslinkable gelatin and hyaluronic acid allows a better control over their
final viscoelastic properties. - The crosslinking kinetics under visible light exposure of the PhotoHA® and
PhotoGel® products from Advanced BioMatrix were successfully measured in real
time with the ElastoSens™ Bio. - Higher concentration of the PhotoHA® and PhotoGel® products accelerated the
crosslinking kinetics and led to stiffer hydrogels. - The crosslinking reaction continued even after light exposure observed by the
continuous increase in the viscoelastic properties. - Higher light intensity accelerated the crosslinking kinetics and led to stiffer hydrogels.
- Light intensity and exposure time can be varied to tune the viscoelasticity of hydrogels according to the application afterwards
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