PhotoHA-Stiff Crosslinking Study

Advanced BioMatrix aims to provide customers and researchers with as much data and information as possible on our products.

The following experiment was conducted to determine the viscoelastic behavior of PhotoHA^®-Stiff (our methacrylated hyaluronic acid) during photocrosslinking at HA concentrations of 1% and 2%, all other parameters remaining equal. 

(For reference, our PhotoHA^®-Soft is a glycidyl methacrylate hyaluronic acid). 

The viscoelastic graphs of PhotoHA^® at 1% and 2% can be seen in Figure 1. While both graphs show similar gelation trends, the final stiffness of the 2% concentration is ~ 4x the stiffness of the 1% concentration. The maximum stiffnesses for all 4 graphs (each concentration run in duplicate) can be seen in Table 1. 

For testing parameters, photoinitiator information, equipment used, concentrations, etc... you can Download the full white paper here.