PureCol and Type III Hydrogels for HIV Study
11/30/23
Publication Title:
An Environmental Restriction Impairs HIV-I Virion Fusion and Triggers Innate Immune Recognition
Advanced BioMatrix Products Used:
PureCol® Type I Collagen, Atelocollagen, 3 mg/ml
How the products were used:
Concentrated HIV virus was added to PureCol and Collagen type III hydrogels to study the impact of tissue-like environments on viral spread.
Article Conclusion:
These results suggest that ERVI represents a broadly acting, tissue-intrinsic barrier to virus spread that reduces the fusogenicity of cell-free virions and sensitizes them for innate immune recognition.
Link to the publication:
https://www.biorxiv.org/content/10.1101/2023.11.22.568261v1.full
