PureCol for Leaky Gut Co-Culture Model
03/28/22
Publication Title:
Leaky Gut Model of the Human Intestinal Mucosa for Testing siRNA-Based Nanomedicine Targeting JAK1
Advanced BioMatrix Products Used:
PureCol® Type I Collagen, Atelocollagen, 3 mg/ml
How the products were used:
PureCol Type I Collagen was used to create a co-culture of Caco-2, THP-1 and MUTZ-3 cells to be used as a leaky-gut model of human intestinal mucosa.
Article Conclusion:
The group has "established a complex in vitro model of the chronically inflamed human intestinal interface for studying anti-inflammatory drugs and nanomedicines. The 3D cell model developed here comprises a sub-confluent epithelial monolayer with adjacent components of the immune system mimicking severe IBD conditions."
Link to the publication:
https://www.sciencedirect.com/science/article/pii/S0168365922001638?via%3Dihub
