PureCol for Leaky Gut Co-Culture Model

PureCol for Leaky Gut Co-Culture Model

03/28/22

Publication Title:

Leaky Gut Model of the Human Intestinal Mucosa for Testing siRNA-Based Nanomedicine Targeting JAK1

 

Advanced BioMatrix Products Used: 

PureCol® Type I Collagen, Atelocollagen, 3 mg/ml

Collagen eBrochure

 

How the products were used:

PureCol Type I Collagen was used to create a co-culture of Caco-2, THP-1 and MUTZ-3 cells to be used as a leaky-gut model of human intestinal mucosa. 

 

 

Article Conclusion:

The group has "established a complex in vitro model of the chronically inflamed human intestinal interface for studying anti-inflammatory drugs and nanomedicines. The 3D cell model developed here comprises a sub-confluent epithelial monolayer with adjacent components of the immune system mimicking severe IBD conditions."

 

Link to the publication:

https://www.sciencedirect.com/science/article/pii/S0168365922001638?via%3Dihub 

 


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