Rat Tail Collagen For Mechanical Regulation
07/19/23
Publication Title:
Inhibitory Effects of Epithelial Cells on Fibrosis Mechanics of Microtissue and Their Spatiotemporal Dependence on the Epithelial-Fibroblast Interaction
Advanced BioMatrix Products Used:
RatCol® - Rat Tail Type I Collagen, 4 mg/ml
How the products were used:
Researchers create a NIH/3T3 fibroblast-laden rat tail collagen hydrogel to provide insights into spatiotemporal regulation of mechanical properties of fibrosis by epithelial cells.
The study provides insights into the densification, stiffness, and contraction force of microtissue co-cultures.
Article Conclusion:
The group concludes that "taken together, this study provides insights into the spatiotemporal regulation of mechanical properties of fibrosis by epithelial cells, and the cocultured microtissue model incorporated with a real-time and sensitive force sensor will be a suitable system for evaluating fibrosis and drug screening."
Link to the publication:
https://pubs.acs.org/doi/full/10.1021/acsbiomaterials.2c01502
