Role of Gap Junctions in Cancer Progression
12/09/20
Publication Title:
Gap Junctions Amplify Spatial Variations in Cell Volume in Proliferating Tumor Spheroids
Advanced BioMatrix Products Used:
FibriCol® type I collagen, 10 mg/ml, atelocollagen
How the products were used:
FibriCol® type I collagen, 10 mg/ml, was used to create a 3D environment in order to study the role of gap junctions in cancer progression.
Article Conclusion:
"We identify how gap junctions can amplify spatial variations in cell volume within multicellular spheroids and, further, describe how the process depends on proliferation-induced solid stress. Our model may provide new insight into the role of gap junctions in breast cancer progression."
Link to the publication:
https://www.nature.com/articles/s41467-020-19904-5
