Stiffness Dependent T Cell Polarization
03/15/24
Publication Title:
T Cell Polarization and NFAT Translocation are Stiffness-Dependent and are Differentially Regulated by Piezol and Orail
Advanced BioMatrix Products Used:
CytoSoft® PDMS Soft Substrate Plates
How the products were used:
CytoSoft® Plates (soft substrate 6-well plates with a thin layer of PDMS of a specific stiffness, including 0.2, 0.5, 2, 8, 16, 32 and 64 kPa) were used to evaluate the affect of matrix stiffness on T cell response against tumor cells.
Article Conclusions:
"Our results demonstrate that tumor cell stiffness directly influences T cell functionality through distinct Ca2+ influx pathways, revealing cell softening as an essential mechanism employed by malignant cells to evade immune surveillance."
Link to the publication:
https://www.biorxiv.org/content/10.1101/2024.03.06.583253v1.full
