Vitronectin and Brain Tumor Study
08/14/23
Publication Title:
ABL1 and ABL2 Promote Medulloblastoma Leptomeningeal Dissemination
Advanced BioMatrix Products Used:
How the products were used:
Vitronectin was used as a coating for culturing cells as part of a medulloblastoma leptomeningeal dissemination study.
Article Conclusion:
Both pharmacologic inhibition of ABL1/2 and ABL1/2 knockdown resulted in decreased expression of c-MYC, identifying a putative signaling pathway, and genes/pathways related to oncogenesis and neurodevelopment were differentially expressed between ABL1/2 knockdown and control medulloblastoma cells.
Link to the publication:
https://academic.oup.com/noa/advance-article/doi/10.1093/noajnl/vdad095/7238388
