Stem Cells in HyStem for Spinal Cord Regeneration
02/05/20
Publication Title:
Human Embryonic Stem Cell-Derived Neural Stem Cells Encapsulated in Hyaluronic Acid (HyStem-C) Promotes Regeneration in a Contusion Spinal Cord Injured Rat
Advanced BioMatrix Products Used:
HyStem®-CThiolated Hyaluronic Acid
How the products were used:
Human embryonic stem cell-derived neural stem cells (hESC-NS) were mixed with HyStem-C and injected into the injured spinal cord model, thus acting as a cell carrier. Data indicated that encapsulated-hESC-NS in HyStem-C can improve animal movement 7 weeks after spinal cord injury.
Article Abstract:
Spinal cord injury (SCI) is a traumatic damage that can causes a loss of neurons around the lesion site and resulting in locomotor and sensory deficits. Currently, there is widely attempts in improvement of treatment strategy and cell delivering to the central nervous system (CNS).
The usage of hyaluronic acid (HA), the main components of the ECM in CNS tissue and neural stem cells (NSCs) niche, is a good selection that can increase of viability and differentiation of NSCs. Importantly, we demonstrate that encapsulation of human embryonic stem cell derived-neural stem cells (hESC-NS) in HyStem-C based hydrogel can increased differentiation these cells into oligodendrocytes and improved locomotor function.
Link to the publication:
https://www.ncbi.nlm.nih.gov/pubmed/31982534
