Electro-Compacted Collagen Cornea
07/21/20
Publication Title:
Biomimetic Corneal Stroma Using Electro-Compacted Collagen
Advanced BioMatrix Products Used:
How the products were used:
Our collagen was electro-compacted into thin films. Cells were seeded onto the films. Current was added to align the collagen fibrils. Films were then successively stacked with each layer orthagonally arranged to create the corneal stroma.
Article Abstract:
Here we describe the construction of an orthogonally oriented 3D corneal stroma model (3D-CSM) using pure electro-compacted collagen (EC). EC films comprise aligned collagen fibrils and support primary human corneal stromal cells (hCSCs). Cell-laden constructs are analogous to the anatomical structure of native human cornea. The hCSCs are guided by the topographical cues provided by the aligned collagen fibrils of the EC films.
Link to the publication:
https://linkinghub.elsevier.com/retrieve/pii/S1742706120303809
