Immunofluorescence Imaging with PureCol
08/10/23
Publication Title:
Multiple Cancers Escape from Multiple MAPK Pathway Inhibitors and Use DNA Replication Stress Signaling to Tolerate Aberrant Cell Cycles
Advanced BioMatrix Products Used:
PureCol® Type I Collagen, Atelocollagen, 3 mg/ml
How the products were used:
Various cancer cells were cultured on PureCol collagen-coated plates prior to immunofluorescence imaging to study tumor tolerance to MAPK pathway inhibitors.
Article Conclusion:
"Our findings suggest that many MAPK pathway–mutant cancers rapidly escape drug action and that suppressing early stress tolerance pathways may achieve more durable clinical responses to MAPK pathway inhibitors."
Link to the publication:
https://www.science.org/doi/full/10.1126/scisignal.ade8744
