Matrix Stiffness Regulations Differentiation
10/15/20
Publication Title:
Periostin and Matrix Stiffness Combine to Regulate Myofibroblast Differentiation and Fibronectin Synthesis During Palatal Healing
Advanced BioMatrix Products Used:
CytoSoft® PDMS coated plates with substrate stiffness of 0.2, 0.5, 2, 8, 16, 32 and 64 kPa.
Advanced BioMatrix CytoSoft eBrochure
How the products were used:
CytoSoft® (coated with PureCol® Type I Collagen) plates with a low stiffness (0.2 kPa) resulted in upregulation of fibronectin in wild-type mice. Also, as the stiffness increased (8 kPa), the fibroblasts increasingly differentiated into myofibroblasts.
