TeloCol-3 3D Cell Culture

Publication Title:

A Novel In Vitro Model of Clinical Cryoablation to Investigate the Transition Zone for Focal Tumor Ablation

Advanced BioMatrix Products Used: 

TeloCol®-3 Type I TeloCollagen, 3 mg/ml

Type I Collagen eBrochure

How the products were used:

TeloCol-3 Collagen was used to create a novel 3D in vitro model of clinical cryoablation to investigate the transition zone for focal tumor ablation. Cells used were murine prostate cancer cell lines. 

Summary: 

Overall, a longer freezing duration, higher freezing intensity, and more freeze thaw cycles led to higher levels of cancer cell death and smaller transition zones. These results have the potential to inform future preclinical research and to improve therapeutic combinations with CA.

 Link to the publication: 

https://www.sciencedirect.com/science/article/abs/pii/S0011224023003437?via%3Dihub