Nutragen Wound Dressing
08/10/23
Publication Title:
Characterization of LL37 Binding to Collagen through Peptide Modification with a Collagen-Binding Domain
Advanced BioMatrix Products Used:
Nutragen® 6 mg/ml type I Atelocollagen
Advanced BioMatrix Collagen eBrochure
How the products were used:
Nutragen® Collagen was mixed with antimicrobial peptides to be used as a collagen-based wound dressing. This publication evaluated modified antimicrobial peptides.
Article Conclusion:
The researchers state that "Electrostatic studies revealed that both LL37 and cCBD-LL37 interact with collagen via long-range electrostatic forces, initiating low-affinity binding that transitions to close-range or hydrophobic interactions. Circular dichroism analysis showed that cCBD-LL37 exhibited enhanced structural stability compared to LL37 under varying ionic strengths and pH conditions, implying potential improvements in antimicrobial activity. Moreover, we demonstrated that the release of LL37 and cCBD-LL37 into the surrounding medium was influenced by the electrostatic environment, but cCBD could enhance the retention of peptide on collagen scaffolds."
