T Cell Killing of Tumor Cells
02/10/22
Publication Title:
Three-Dimensional Colon Cancer Organoids Model the Response to CEA-CD3 T-Cell Engagers
Advanced BioMatrix Products Used:
PureCol® EZ Gel Type I Collagen, Atelocollagen, 3 mg/ml
How the products were used:
PureCol EZ Gel Type I Collagen hydrogels were used for the assessment of T cell mediated killing of tumor cells in cocultures with tumor organoids.
Article Conclusion:
Three-dimensional tumor cocultures with T cells using live confocal microscopy provide suitable models to test the requirements for colon-cancer redirected killing as elicited by CEA-targeted T-cell engagers undergoing clinical trials and treatment allow combinations to be tested in a relevant preclinical system.
Link to the publication:
